Hair Science Institute Researches the embryonic development of human follicular units


Hair disorders such as alopecia often have an important social and psychological influence on patients. This also applies to those who have lost their hair because they suffer from severe burns. Hair follicles stimulate proper wound healing and prevent scar formation. The research carried out on hair follicles or follicular units is useful for those numerous patients who are suffering from alopecia problems.

Research applied to capillary growth

There are studies intensively applied to hair growth and the disorders that afflict them. The study of follicular units is not yet completed. Research on human fetal material is often restricted. So the results, studies, diseases and wound healing very often remain dependent on animal studies. These studies are very expensive in terms of money and long as time.

Although animal experience has produced and provided considerable and useful information, it is still recognised that there are differences between animal skin and human skin. It is therefore necessary to obtain results on human models that are significant. The models used for human diseases could therefore be essential for future therapy aimed at healing these problems. Three-dimensional structures consisting of the patient’s hair and hair stem cells can be used for these researches. Knowledge of the genesis of hair, that is, how it develops, is absolutely essential.

The study of the mechanisms underlying the formation of follicular units

It is important to discover and define the mechanisms underlying the formation of follicular units within human fetal skin. Determine how progenitor cells are formed and how hair is subsequently formed within the follicular unit. These laboratory cell studies have shown that all these organs can be organized into models that mimic embryos and use morphogenesis, proteins and extracellular matrix. Knowledge of cellular proteins in the skin of human fetuses is fundamental to understanding epithelial tissues, including skin appendages. The aim is to provide an overview of our current understanding of cellular mutations that occur during the development of human skin and follicular unity.

HASCI’s research aimed at the genetic knowledge of follicular units

Hasci evaluated the potential of this molecular growth process to apply this knowledge to the creation of an in vitro model on humans using human skin containing hair follicles. The development of the human hair follicle occurs during embryogenesis in the second trimester of gestation. This process is an interaction that depends on a variety of biochemical forms. The process results in the differentiation of the different components of the follicular unit.

Studies conducted by HASCI on human and animal embryos

Although much progress has been made, the application of cell therapies to hair loss has not progressed. This is probably due to a lack of knowledge about the ergonomic mechanisms of human organogenesis. The lack of adequate studies on the human embryo hinders research on the neurogenesis of the follicular unit in vitro. Most studies on follicular unit organogenesis have focused on the biomolecular aspects rather than on the neurogenesis of the follicular unit in vitro. It will not be enough to describe the cellular and molecular morphological stages of the human fetus, but it is also necessary to focus on the influence that the extracellular matrix has on the growth of the follicular unit. Since the availability of human data is scarce, research on other species also had to be used.

The Hair Science Institute: at the forefront of this research

The current knowledge on the development of the follicular unit in the human fetus can be completed with techniques reproducing molecular cell production in the Neurogenesis of the Follicular Unit in vivo. Hasci based his research on the reproduction of follicular units via in vivo cloning and the hair stem cell transplantation capillary restoration technique, Hair Stemcel transplantation, HST is the embodiment of this research.

Hasci studied the evolution in the human fetus of follicular unit genesis

During the creation of follicular units in the fetus during organogenesis of follicular units, epithelial cells interact with surrounding dermal cells. The latter proliferate and form a condensate. With the formation of the pre-dermal condensate begins the next phase of formation of the follicular unit in organogenesis. As condensate formation progresses, the concentration of cells around it increases and the induction of the follicular unit of adjacent epidermal cells is inhibited.

The study of the evolution of follicular units led to the HST technique

During the development phase of the cells, the latter differentiate into all components of the follicular unit, including the inner root sheet, the outer root sheet and the hair shaft. Studies by leading scientists have revealed that developing regions of follicular unity give rise to hair shaft. They are closely linked. If either pathway is blocked during the cytodifferentiation phase, the follicular units convert into cysts. Hair follicle development involves a complex interaction of reciprocal epithelial mesenchymal signals. Most cells are controlled by a mutual interaction. Laminae and collagens are the two main fibrous protein systems of the skin that are at the origin of the development of the follicular unit.


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